Jocul „Mass Effect 2” este în prima poziţie pe lista „Cele mai bune jocuri ale anului 2010” întocmită de site-ul GameTrailers.com. Această informaţie a fost făcută publică de portalul ScienceFiction.com. Lista oferită de Game Trailes selectează cele mai bune titluri dintr-un număr de 160 de jocuri de diferite genuri şi dedicate unor platforme diferite:
Best Puzzle Game: Super Scribblenauts (Warner Bros.)
Best Strategy Game: StarCraft II: Wings of Liberty (Blizzard)
Best New IP: Bayonetta (Sega)
Best Racing Game: Gran Turismo 5 (SCEA)
Best PSP Game: God of War: Ghost of Sparta (SCEA)
Best Nintendo DS Game: Dragon Quest IX: Sentinels of the Starry Skies
(Nintendo)
Best Action/Adventure Game: God of War III (SCEA)
Best Platformer: Super Mario Galaxy 2 (Nintendo)
Best Sports Game: NBA 2K11 (2K Games)
Best Role-Playing Game: Mass Effect 2 (Electronic Arts)
Most Innovative: OnLive
Best Motion Game: Dance Central (MTV Games)
Best Story: Mass Effect 2 (Electronic Arts)
Best Third-Person Shooter: Red Dead Redemption (Rockstar Games)
Biggest News Story: Nintendo 3DS
Best Downloadable Game: Super Meat Boy (Team Meat)
Best Expansion: World of Warcraft (Blizzard)
Best Fighting Game: Super Street Fighter IV (Capcom)
Best Music & Rhythm Game: Rock Band 3 (MTV Games)
Best Graphics: God of War III (SCEA)
Best First-Person Shooter: Call of Duty: Black Ops (Activision)
Best Trailer: BioShock Infinite
Best Software-Lineup: Xbox 360
Best Multiplayer Game: StarCraft II: Wings of Liberty (Blizzard)
Biggest Surprise: Minecraft (Mojang Specifications)
Best PC Game: Mass Effect 2 (Electronic Arts)
Best Wii Game: Super Mario Galaxy 2 (Nintendo)
Best PlayStation 3 Game: Red Dead Redemption (Rockstar Games)
Best Xbox 360 Game: Mass Effect 2 (Electronic Arts)
Best Single-Player Campaign: Mass Effect 2 (Electronic Arts)
Game of the Year: Mass Effect 2 (Electronic Arts)