Jocul „Mass Effect 2” este în prima poziţie pe lista „Cele mai bune jocuri ale anului 2010” întocmită de site-ul  GameTrailers.com. Această informaţie a fost făcută publică de portalul ScienceFiction.com. Lista oferită de Game Trailes selectează cele mai bune titluri dintr-un număr de 160 de jocuri de diferite genuri şi dedicate unor platforme diferite:

Best Puzzle Game: Super Scribblenauts (Warner Bros.)

Best Strategy Game: StarCraft II: Wings of Liberty (Blizzard)

Best New IP: Bayonetta (Sega)

Best Racing Game: Gran Turismo 5 (SCEA)

Best PSP Game: God of War: Ghost of Sparta (SCEA)

Best Nintendo DS Game: Dragon Quest IX: Sentinels of the Starry Skies

(Nintendo)

Best Action/Adventure Game: God of War III (SCEA)

Best Platformer: Super Mario Galaxy 2 (Nintendo)

Best Sports Game: NBA 2K11 (2K Games)

Best Role-Playing Game: Mass Effect 2 (Electronic Arts)

Most Innovative: OnLive

Best Motion Game: Dance Central (MTV Games)

Best Story: Mass Effect 2 (Electronic Arts)

Best Third-Person Shooter: Red Dead Redemption (Rockstar Games)

Biggest News Story: Nintendo 3DS

Best Downloadable Game: Super Meat Boy (Team Meat)

Best Expansion: World of Warcraft (Blizzard)

Best Fighting Game: Super Street Fighter IV (Capcom)

Best Music & Rhythm Game: Rock Band 3 (MTV Games)

Best Graphics: God of War III (SCEA)

Best First-Person Shooter: Call of Duty: Black Ops (Activision)

Best Trailer: BioShock Infinite

Best Software-Lineup: Xbox 360

Best Multiplayer Game: StarCraft II: Wings of Liberty (Blizzard)

Biggest Surprise: Minecraft (Mojang Specifications)

Best PC Game: Mass Effect 2 (Electronic Arts)

Best Wii Game: Super Mario Galaxy 2 (Nintendo)

Best PlayStation 3 Game: Red Dead Redemption (Rockstar Games)

Best Xbox 360 Game: Mass Effect 2 (Electronic Arts)

Best Single-Player Campaign: Mass Effect 2 (Electronic Arts)

Game of the Year: Mass Effect 2 (Electronic Arts)